ADMELOG is a fast-acting mealtime insulin that helps to control blood sugar. It is designed to attempt to mimic your body’s natural insulin response to blood sugar spikes after meals. It is to be taken 15 minutes before meals or immediately after.

ADMELOG contains insulin lispro (100 Units/mL), a man-made insulin.

Long-acting insulin (along with diet and exercise) may not be enough to control your blood sugar spikes. That may be why your doctor has recommended adding ADMELOG.

Unlike long-acting insulin you take once a day, ADMELOG is a fast-acting insulin you take at mealtimes to help you manage blood sugar spikes that happen after you eat. It may also help to lower your A1c.

Yes, both Humalog® and ADMELOG:

  • Are fast-acting mealtime insulins that work to control blood sugar when you eat.
  • Help control blood sugar spikes and lower A1c.
  • Are taken within 15 minutes before or immediately after a meal.
  • Can be stored at room temperature below 86°F for up to 28 days after first use.

For full safety information, see full Prescribing Information for ADMELOG.

Please be sure to review the possible side effects with your doctor.


Do not use ADMELOG if you:

  • Have low blood sugar (hypoglycemia).
  • Have an allergy to ADMELOG or any of the ingredients in ADMELOG. See the end of the Patient Information leaflet for a complete list of ingredients in ADMELOG.

You should ask your doctor which medicines (including over-the-counter and other prescription medicines, and vitamins and herbal supplements) are safe to take if you are using ADMELOG.

Taking certain diabetes pills called TZDs (thiazolidinediones) with ADMELOG may cause heart failure in some people. This can happen even if you have never had heart failure or heart problems before. If you already have heart failure, it may get worse while you take TZDs with ADMELOG. Your healthcare provider should monitor you closely while you are taking TZDs with ADMELOG.

Tell your healthcare provider if you have any new or worse symptoms of heart failure, including:

  • Shortness of breath.
  • Swelling of your ankles or feet.
  • Sudden weight gain.

Treatment with TZDs and ADMELOG may need to be adjusted or stopped by your healthcare provider if you have new or worse heart failure.

Be sure to tell your healthcare provider about all of your medical conditions, including if you:

  • Have liver or kidney problems.
  • Take other medicines, especially ones commonly called TZDs (thiazolidinediones).
  • Have heart failure or other heart problems. If you have heart failure, it may get worse while you take TZDs with ADMELOG.
  • Are pregnant, planning to become pregnant, or are breastfeeding. It is not known if ADMELOG may harm your unborn or breastfeeding baby.

All of the medicines you take, including:

  • Prescription medicines.
  • Over-the-counter medicines.
  • Vitamins.
  • Herbal supplements.

Before you start using ADMELOG, talk to your healthcare provider about low blood sugar and how to manage it.

  • Read the detailed Instructions for Use that come with your ADMELOG.
  • Speak with your healthcare provider about how to use ADMELOG, and use it exactly as directed.
  • Know the amount of ADMELOG you use. Do not change the amount of ADMELOG you use unless your healthcare provider tells you to. The amount of insulin and the best time for you to take your insulin may need to change if you take a different type of insulin.
  • Check your insulin label each time you inject to make sure you are using the correct insulin.
  • Do not reuse needles. Using a new needle for each injection lowers your risk of getting an infection or getting the wrong dose of ADMELOG due to a blocked needle.
  • Keep out of reach of children.

You can take ADMELOG using:

  • A SoloStar® disposable prefilled injection pen.
  • A syringe and vial.
  • An insulin pump.

Speak to your doctor about what option may be appropriate for you.

You should take ADMELOG within 15 minutes before or right after eating a meal.

You can inject ADMELOG in four areas of your body:

  • Anywhere in your stomach area, except for a two-inch radius around your navel.
  • In the fatty tissue on the outer back area of your upper arm.
  • In your thigh, away from your knee.
  • Or buttocks.

Each time you inject a new dose, be sure to change (rotate) your injection site within the area you have selected.

DO NOT use the same exact spot for each injection.

Your dose of ADMELOG may need to change because of:

  • A change in physical activity or exercise.
  • Changes in meal patterns.
  • Weight gain or loss.
  • Increased stress.
  • Illness.
  • A change in diet.
  • Changes in kidney or liver functions.
  • Or other medicines you take.

Before first use

  • Keep new pens in the refrigerator between 36° F and 46° F (2°C and 8°C) until the expiration date. Discard if expired.
  • Do not freeze. Do not use ADMELOG if it has been frozen.

After first use

  • Keep your pen at room temperature below 86°F (30°C).
  • Must be used within 28 days after first use.
  • Keep your pen away from heat or light.
  • Store your pen with the pen cap on.
  • Do not put your pen back in the refrigerator.
  • Do not store your pen with the needle attached.
  • Keep out of the reach of children.

You should only use your pen for up to 28 days after its first use. Throw away the ADMELOG SoloStar® pen you are using after the 28th day, even if it still has insulin left in it.

Be sure to put used needles and syringes in a FDA-cleared disposal container right away after use.

While using ADMELOG, do not:

  • Drive or operate heavy machinery, until you know how ADMELOG affects you.
  • Drink alcohol or use prescription or over-the-counter medicines that contain alcohol.

Side Effects

The most common side effects of ADMELOG include:

  • Low blood sugar (hypoglycemia).
  • Allergic reactions, including reactions at the injection site, skin thickening or pits at the injection site (lipodystrophy), itching, and rash.

These are not all the possible side effects of ADMELOG. It is important to review the labeling that comes with your ADMELOG prescription and speak to your doctor about all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

ADMELOG may cause serious side effects that can lead to death, including:

  • Low blood sugar (hypoglycemia).
  • Serious allergic reactions (whole body reaction).
  • Low potassium in your blood (hypokalemia).
  • Heart failure.

Get emergency medical help right away if you have:

  • Any of these signs or symptoms of a severe allergic reaction: a rash over your whole body, trouble breathing, a fast heartbeat, feeling faint, sweating, swelling of your face, tongue, or throat.
  • Extreme drowsiness, dizziness, or confusion.